Center for Omics & Systems Medicine (C-OSM)

General Medicine

Center for Omics & Systems Medicine (C-OSM)

In a visionary and philanthropic stride toward shaping the future of scientific research and national development, the academic leadership of Nitte (Deemed to be University), under the guidance of Hon’ble Chancellor Shri N. Vinaya Hegde, proposes the establishment of a specialized, state-of-the-art facility dedicated to advanced multi-omics research.

The Center for Omics & Systems Medicine (C-OSM) will serve as a premier national hub for cutting-edge investigations in genomics, proteomics, metabolomics, interactomics, and systems-level biology across human diseases, livestock health, and medicinally and economically important plants.

By enabling the discovery, development, and validation of high-value biomarkers, diagnostics, therapeutic targets, and vaccine candidates, the center will accelerate translational research and foster innovation. Through strategic industry partnerships and robust Technology Transfer mechanisms, C-OSM aims to drive employment generation, stimulate biotech entrepreneurship, and contribute to sustainable national wealth creation—positioning Nitte (DU) as a leader in India’s next-generation omics and biotechnology ecosystem.

Vision:
To emerge as a global leader in integrative omics and systems medicine, driving discovery, innovation, and translation for precision health. By uniting cutting-edge technologies in genomics, proteomics, metabolomics, and advanced data science, the center will deepen the understanding of complex diseases and enable impactful clinical applications that advance human and societal well-being.

Mission:
Advance Multi-Omics Research: Establish next-generation platforms for proteogenomics, phosphoproteomics, metabolomics, and high-resolution mass spectrometry to unravel biological complexity at unprecedented depth.

Promote Systems Medicine:
Integrate multi-omics datasets with computational modelling, AI-driven analytics, and network biology approaches to derive systems-level insights into human health and disease.

Enable Translation & Innovation:
Discover, validate, and advance biomarkers, diagnostics, therapeutic targets, and vaccine candidates for major global health priorities-including cancer, infectious diseases, neurological disorders, and metabolic syndromes.

Build Capacity & Talent:
Train and nurture the next generation of scientists, clinicians, and data scientists through specialized academic programs, hands-on research, and global collaborative exposure.

Collaborate, Lead & Impact:
Forge strong partnerships with national and international academic institutions, industries, and healthcare organizations to create impactful translational pipelines and contribute to India’s innovation and biotechnology leadership.

            

Programs - Ph.D

The Center for Omics and Systems Medicine (C-OSM) offers opportunities for talented young researchers to pursue full-time research on current and impactful topics. Under the Faculty of Biological Sciences, selected candidates receive fellowship support from the University. In addition, research positions under ongoing funded projects are available, with the option to register for a Ph.D. as Junior Research Fellows.

The Center aims to foster collaboration between biologists and clinicians while using advanced OMICs technologies to explore the molecular basis of human diseases, host-pathogen interactions, metabolism, therapeutic responses, drug targets including traditional medicines, and mechanisms of drug resistance. Our team includes experts in mass spectrometry, molecular biology, data science, programming, and clinical research, working together to advance the molecular understanding of biology. We are inviting applications from dedicated individuals to join as Junior Research Fellows, with the possibility to progress into Ph.D. programs at Nitte DU. Fellows will work on diverse biological research questions, including infectious diseases, cancer biology, large-scale data analysis, data integration, and biological databases. Research activities will involve genomic, proteomic, metabolomic, and molecular biology techniques to discover molecular mechanisms, signaling networks, and metabolic alterations, always with a focus on meaningful translational outcomes. Candidates with a Master’s degree in any Life Science or Chemistry discipline and a strong passion for research are encouraged to apply.

Faculty of Biological Sciences and For more about the Ph.D. program at NitteDU https://nitte.edu.in/phd.php

C-OSM Publications

  • Parate SS, Rehas R, Gupta S, George LS, Mahammad N, Unni A, TR S, Manuel S, Shaji V, Krishna SV A, George M. BC-Predict Database: A Curated Resource of Experimentally Validated Markers in Multidrug Resistance in Breast Cancer. bioRxiv. 2025:2025-10.
  • Ramesh P, Upadhyay SS, Thomas SD, Sorake CJ, MK G, Shetty VV, Modi PK, Shetty R, Vijayakumar M, Codi JA, Prasad TS. Differentiating Gastric Cancers from Acid Peptic Diseases through Integrative Targeted Proteomics and Machine Learning Approaches. Journal of Proteome Research. 2025 Sep 17;24(10):5159-76.
  • Upadhyay, S. S., Parate, S., D’Souza, U., Kurian, A., Biradar, S. Bhat, G., Sadananda, V., and Prasad, T. S. K. (2025). An integrative omics and network pharmacology approach to evaluate the anti-ulcer activity of _Bombax ceiba_ L. gum in rats. In press.